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. 2017 Jan 19;8:2. doi: 10.3389/fphar.2017.00002

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Copyright © 2017 Lou, Teng, Zhang, Yang, Ma, Wang, Tian, An, Yang, Zhang, Xu and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HE staining showed the effects of HPβCD/BCP on morphologic changes in hippocampal neurons caused by 2VO: sham group (A), 2VO group (B), HPβCD/BCP low dose group (C), HPβCD/BCP middle dose group (D), HPβCD/BCP high dose group (E), and AM630 group (F). In the 2VO group, neurons were paramorphia, their nuclei became triquetrous or polygonous, and the nerve fibers were fractured and reduced. In the HPβCD/BCP group, less abnormal neurons were observed. In the AM630 group, the neurons were triquetrous and wedge-shaped, the nuclei were irregular, the cytoplasm was aggregated and the nerve fibers were fractured and reduced. The red arrows showed the nerve fibers and the black arrows showed the abnormal neurons. The bar is 100 μm.