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. 2017 Jan 19;8:2. doi: 10.3389/fphar.2017.00002

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Copyright © 2017 Lou, Teng, Zhang, Yang, Ma, Wang, Tian, An, Yang, Zhang, Xu and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expressions of CB2, PI3K and Akt in rats' brain tissues of different groups. The expression levels of the CB2 and PI3K increased slightly in the 2VO group compared with those in the sham group. After HPβCD/BCP treatment, the expression levels of CB2 and P13K, p-Akt increased compared with those of the 2VO group, whereas these levels decreased in the AM630 treated group. (^*P < 0.05 vs. sham group, ^#P < 0.05 vs. 2VO group, ^##P < 0.01 vs. 2VO group).