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. 2017 Jan 19;8:2. doi: 10.3389/fphar.2017.00002

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Copyright © 2017 Lou, Teng, Zhang, Yang, Ma, Wang, Tian, An, Yang, Zhang, Xu and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MWM test results of rats' performance. (A) Visible platform task on the first day. (B) Mean escape latency calculated for each day in sham, 2VO, BCP treated low-dose, middle dose, high dose and AM630 treated group in navigation test. Results of (C) times of crossing platform, (D) time of aim quadrant, (E) path length of each group in spatial probe tests. All the rats reached the platform in the visible platform task on the first day. The rats in the 2VO group and AM630 group performed longer escape latencies than other groups in the MWM training. Compared with rats in the sham group and BCP treated groups, rats in the 2VO group and AM630 group exhibited less times of crossing platform, time of staying at the aim quadrant and path length at aim quadrant. (^*P < 0.05 vs. sham group, ^#P < 0.05 vs. 2VO group, ^##P < 0.001 vs. 2VO group).