Table 1.
Yeast two-hybrid analysis of interactions of the PAKc and PAKa CRIB domains with constitutively active and dominant-negative Rho family GTPases
| Rho GTPase | Interaction |
|
|---|---|---|
| PAKa | PAKc | |
| Rac1a Q61L | +++ | +++ |
| Rac1a T17N | − | − |
| Rac1b G12V | +++ | +++ |
| Rac1c G12V | +++ | +++ |
| RacA G12V | +++ | +++ |
| RacA S17N | − | − |
| RacB G12V | ++++ | +++++ |
| RacB Q61L | ++++ | +++++ |
| RacB T17N | − | − |
| RacC G15V | − | + |
| RacC T20N | − | − |
| RacD G17V | − | − |
| RacE G20V | − | − |
| RacF1 G12V | − | − |
| RacF2 G12V | − | − |
| RacG G12V | − | − |
| RacH M13V | − | − |
| RacI S14V | − | − |
| RacJ D18V | − | − |
| RacL G12V | − | − |
| HsRac1 G12V | +++ | +++ |
| HsRac1 T17N | − | − |
| HsCdc42 G12V | +++ | +++ |
| HsCdc42 T17N | − | − |
| HsRhoA G14V | − | − |