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. 2017 Jan 19;7:687. doi: 10.3389/fimmu.2016.00687

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Copyright © 2017 Moncayo, Lin, McCarthy, Watson and O’Callaghan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MICA expression correlates with increased natural killer (NK) cell-mediated cytotoxicity. (A) U2OS cells were either plated to grow as non-confluent adherent cells, as confluent adherent cells or were cultured in suspension. After 5 days, cells were exposed to NK cells in a chromium-release assay. (B) Non-confluent cells and spheroids were also subjected to NK cells pretreated with a blocking NKG2D antibody. (C) Adherent U2OS and (D) HeLa cells were either mock-treated or treated with the focal adhesion kinase inhibitor AG82 prior to exposure to NK cells in a chromium-release assay. Points plotted represent mean of four replicates. Error bars show SEMs. To test for significance, a Student’s t-test was performed with the degree of cytotoxicity values of each ratio against the other conditions. *p < 0.05, **p < 0.01.