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CDDP induces oxidative stress in wild-type but not in Rho0 cells. The wild-type yeast strain (black bars) and Rho0 strain (white bars) were challenged with increasing concentrations of cisplatin for 3 hr. DCF fluorescence was determined and normalized for cell density. ROS formation is expressed as percentage fluorescence compared with untreated wild-type or Rho0 cells (100%) Data are representative of mean ± SD of three different cell isolates
