Table 2. Cox proportional hazard regression analysis for overall survival.

	Univariatea		Multivariateb
Factor	P-valuec	HR	95%CI	P-valuec
Gender
Male vs female	0.6793		—
Age (years)
⩾60 vs <60	0.0294		—
Location
Upper vs middle/lower	0.0296	2.776	1.125–6.27	0.0282
Histological grade
Undifferentiated vs differentiated	0.8722		—
Macroscopic appearance
Type 3/4/5 vs type 0/1/2	<0.0001
Tumour size (mm)
⩾60 vs <60	<0.0001	2.842	1.336–6.44	0.0063
Venous invasion
Positive vs negative	<0.0001		—
Lymphatic invasion
Positive vs negative	<0.0001		—
pT-stage
pT 2/3/4 vs pT 1	<0.0001	14.48	1.611–310.70	0.0164
pN-stage
pN 1/2/3 vs pN 0	<0.0001	4.14	1.242–23.31	0.0174
PBK/TOPK expressiond
High vs low	0.0009	6.403	2.712–14.49	<0.0001
p53 (DO7)
Positive vs negative	0.5273

Abbreviations: CI=confidence interval; HR=hazard ratio.

Statistically significant values are in boldface type.

^aKaplan and Meier method, and the statistical significance was determined by log-rank test.

^bMultivariate survival analysis was performed using Cox's proportional hazard model.

^cP-values were from two-sided tests and were statistically significant at <0.05.

^dPBK/TOPK expression was evaluated by immunohistochemical analysis as described in Materials and Methods.