Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Structure of O-acetyl-GD2 CAR examples. (a) An O-acetyl-GD2-specific mAb derived scFv is linked through a spacer and a transmembrane domain to the T cell receptor (TCR) complex CD3ζ chain intracellular signaling domain. (b) Additional costimulatory endodomains are shown in 2nd- and 3rd-generation CARs derived from CD28 or CD28 and 41BB, respectively. ∗41BB may be exchanged to other domains such as OX40 or ICOS.
