Table 1.

Relevant characteristic of O-acetyl-GD2 ganglioside as a cancer antigen according to Cheever et al. [26].

Criteria	Data on O-acetyl-GD2
Therapeutic function	Preclinical data showing that anti-O-acetyl-GD2 mAbs induce tumor cell death by immunological and nonimmunological mechanisms [39, 80, 87, 104].
Immunogenicity	Poorly immunogenic [95].
Oncogenicity	Increased expression in adult and pediatric solid tumors, to be determined with a clear association with oncogenic process [39, 40, 65, 87].
Expression level and positive cell	Overexpressed in cancer with little or no expression in normal tissues [39].
Stem cell expression	Expression on cancer with cancer stem cell issue such as glioblastoma, but without information about putative stem cells [87].
Number of patients with antigen-positive cancers	High level of expression in >70% of patients with a particular cancer type [39, 87].
Number of epitopes	Short antigenic segment with one or few epitopes [95].
Cellular location of expression	Expressed on the cell surface [39, 87] with little or no circulating antigen [104].