Table 2.
Bivariate associations of receipt of vaccine with new diagnosis.a
| Vaccine | Broken bone N = 85,151 | Open wound N = 73,290 | OCD N = 3,222 | Anorexia nervosa N = 551 | Anxiety disorder N = 23,462 | Tic disorder N = 2,547 | ADHD N = 46,640 | Major depression N = 13,295 | Bipolar disorder N = 5,892 | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hazard ratio (HR) | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | ||||||||||
| Any vaccine | |||||||||||||||||||||||||||
| 3 months | 1.04 | 1.00 | 1.08 | 0.96 | 0.92 | 1.00 | 1.23 | 1.02 | 1.49 | 1.80 | 1.21 | 2.68 | 1.12 | 1.04 | 1.20 | 1.11 | 0.90 | 1.38 | 1.06 | 1.00 | 1.12 | 0.88 | 0.80 | 0.97 | 0.87 | 0.75 | 1.01 |
| 6 months | 1.08 | 1.05 | 1.11 | 0.97 | 0.94 | 1.01 | 1.27 | 1.10 | 1.47 | 1.63 | 1.17 | 2.27 | 1.13 | 1.07 | 1.19 | 1.25 | 1.06 | 1.47 | 1.04 | 1.00 | 1.09 | 0.92 | 0.86 | 0.99 | 0.82 | 0.73 | 0.91 |
| 12 months | 1.07 | 1.04 | 1.09 | 0.97 | 0.94 | 1.00 | 1.23 | 1.09 | 1.38 | 1.47 | 1.12 | 1.93 | 1.14 | 1.09 | 1.19 | 1.19 | 1.04 | 1.36 | 1.08 | 1.05 | 1.12 | 0.89 | 0.84 | 0.95 | 0.87 | 0.79 | 0.95 |
| Influenza | |||||||||||||||||||||||||||
| 3 months | 1.03 | 0.96 | 1.11 | 0.93 | 0.86 | 1.01 | 1.36 | 1.02 | 1.82 | 2.20 | 1.10 | 4.38 | 1.23 | 1.10 | 1.38 | 1.24 | 0.91 | 1.67 | 0.98 | 0.91 | 1.07 | 0.81 | 0.68 | 0.96 | 0.71 | 0.55 | 0.92 |
| 6 months | 1.07 | 1.02 | 1.13 | 0.96 | 0.91 | 1.02 | 1.48 | 1.21 | 1.83 | 1.83 | 1.07 | 3.15 | 1.24 | 1.14 | 1.35 | 1.27 | 1.02 | 1.58 | 0.97 | 0.91 | 1.02 | 0.89 | 0.79 | 1.00 | 0.84 | 0.70 | 1.00 |
| 12 months | 1.06 | 1.02 | 1.09 | 0.97 | 0.93 | 1.01 | 1.35 | 1.16 | 1.59 | 1.52 | 0.99 | 2.34 | 1.27 | 1.19 | 1.35 | 1.28 | 1.08 | 1.50 | 1.04 | 0.99 | 1.09 | 0.93 | 0.84 | 1.02 | 0.87 | 0.76 | 1.00 |
| TD | |||||||||||||||||||||||||||
| 3 months | 1.02 | 0.94 | 1.11 | 0.92 | 0.83 | 1.02 | 1.15 | 0.72 | 1.84 | 1.70 | 0.78 | 3.71 | 0.95 | 0.80 | 1.13 | 0.86 | 0.47 | 1.60 | 1.04 | 0.91 | 1.19 | 0.95 | 0.78 | 1.16 | 0.83 | 0.62 | 1.12 |
| 6 months | 1.07 | 1.00 | 1.14 | 0.94 | 0.87 | 1.01 | 1.07 | 0.75 | 1.51 | 1.77 | 0.90 | 3.49 | 0.91 | 0.80 | 1.03 | 1.24 | 0.82 | 1.88 | 1.03 | 0.93 | 1.13 | 0.96 | 0.83 | 1.10 | 0.82 | 0.66 | 1.02 |
| 12 months | 1.07 | 1.02 | 1.12 | 0.93 | 0.88 | 0.98 | 0.99 | 0.77 | 1.26 | 1.63 | 1.05 | 2.52 | 0.98 | 0.90 | 1.07 | 0.93 | 0.67 | 1.30 | 1.04 | 0.97 | 1.11 | 0.90 | 0.82 | 1.00 | 0.80 | 0.68 | 0.93 |
| HepA | |||||||||||||||||||||||||||
| 3 months | 1.02 | 0.94 | 1.12 | 0.97 | 0.88 | 1.07 | 1.47 | 0.92 | 2.33 | 1.60 | 0.52 | 4.89 | 1.00 | 0.85 | 1.18 | 1.13 | 0.70 | 1.83 | 1.03 | 0.92 | 1.17 | 0.86 | 0.68 | 1.08 | 1.03 | 0.73 | 1.47 |
| 6 months | 1.05 | 0.98 | 1.12 | 0.99 | 0.92 | 1.07 | 1.43 | 1.02 | 2.01 | 1.09 | 0.48 | 2.51 | 1.08 | 0.95 | 1.22 | 1.35 | 0.92 | 1.98 | 1.05 | 0.96 | 1.15 | 0.95 | 0.81 | 1.13 | 0.79 | 0.60 | 1.03 |
| 12 months | 1.08 | 1.02 | 1.13 | 0.99 | 0.93 | 1.05 | 1.40 | 1.07 | 1.82 | 1.73 | 0.89 | 3.37 | 1.00 | 0.91 | 1.10 | 1.17 | 0.88 | 1.56 | 1.09 | 1.02 | 1.18 | 0.97 | 0.86 | 1.11 | 0.81 | 0.66 | 1.00 |
| HepB | |||||||||||||||||||||||||||
| 3 months | 1.08 | 0.93 | 1.25 | 1.05 | 0.89 | 1.24 | 0.71 | 0.32 | 1.61 | 3.00 | 0.61 | 14.86 | 1.01 | 0.76 | 1.34 | 1.40 | 0.44 | 4.41 | 1.13 | 0.91 | 1.39 | 1.05 | 0.77 | 1.43 | 0.97 | 0.61 | 1.56 |
| 6 months | 1.02 | 0.92 | 1.13 | 1.02 | 0.91 | 1.15 | 0.80 | 0.45 | 1.44 | 1.71 | 0.68 | 4.35 | 1.01 | 0.83 | 1.23 | 1.17 | 0.54 | 2.52 | 1.07 | 0.92 | 1.24 | 0.89 | 0.71 | 1.11 | 0.91 | 0.64 | 1.29 |
| 12 months | 1.03 | 0.95 | 1.11 | 1.00 | 0.91 | 1.09 | 0.93 | 0.60 | 1.44 | 1.55 | 0.72 | 3.30 | 1.01 | 0.89 | 1.16 | 1.19 | 0.61 | 2.31 | 1.06 | 0.95 | 1.18 | 1.00 | 0.85 | 1.18 | 1.07 | 0.83 | 1.38 |
| Meningitis | |||||||||||||||||||||||||||
| 3 months | 1.05 | 0.95 | 1.17 | 1.04 | 0.92 | 1.19 | 1.10 | 0.67 | 1.80 | 1.71 | 0.68 | 4.35 | 1.06 | 0.88 | 1.27 | 1.46 | 0.72 | 2.95 | 1.16 | 0.98 | 1.38 | 0.89 | 0.70 | 1.13 | 0.87 | 0.57 | 1.33 |
| 6 months | 1.08 | 1.00 | 1.17 | 1.02 | 0.92 | 1.12 | 1.15 | 0.78 | 1.71 | 1.75 | 0.86 | 3.56 | 1.12 | 0.97 | 1.29 | 1.94 | 1.08 | 3.46 | 1.08 | 0.95 | 1.23 | 0.88 | 0.73 | 1.05 | 0.82 | 0.61 | 1.11 |
| 12 months | 1.06 | 0.99 | 1.14 | 1.02 | 0.94 | 1.10 | 1.34 | 0.96 | 1.87 | 1.42 | 0.79 | 2.56 | 1.14 | 1.01 | 1.29 | 1.73 | 1.07 | 2.80 | 1.06 | 0.95 | 1.18 | 0.81 | 0.70 | 0.94 | 0.85 | 0.67 | 1.09 |
| Varicella | |||||||||||||||||||||||||||
| 3 months | 0.88 | 0.79 | 0.99 | 0.90 | 0.79 | 1.03 | 1.33 | 0.79 | 2.26 | 1.00 | 0.20 | 4.96 | 1.06 | 0.85 | 1.31 | 0.73 | 0.42 | 1.27 | 1.06 | 0.90 | 1.24 | 0.85 | 0.58 | 1.24 | 1.08 | 0.63 | 1.87 |
| 6 months | 0.97 | 0.88 | 1.06 | 0.96 | 0.87 | 1.07 | 1.38 | 0.89 | 2.15 | 2.66 | 0.71 | 10.04 | 1.17 | 0.99 | 1.38 | 0.91 | 0.59 | 1.40 | 1.09 | 0.97 | 1.23 | 0.85 | 0.64 | 1.14 | 0.79 | 0.52 | 1.21 |
| 12 months | 1.00 | 0.93 | 1.08 | 0.93 | 0.85 | 1.01 | 1.36 | 0.92 | 1.99 | 1.29 | 0.48 | 3.45 | 1.11 | 0.97 | 1.28 | 0.97 | 0.67 | 1.40 | 1.06 | 0.95 | 1.17 | 0.84 | 0.66 | 1.06 | 0.74 | 0.53 | 1.05 |
aCases and controls matched on date (±15 days, see text) of the start of continuous enrollment, year of birth, gender, and three-digit zip code. N’s represent cases only. Results in bold are statistically significant at p < 0.05.
OCD, obsessive–compulsive disorder; ADHD, attention deficit hyperactivity disorder; TD, tetanus and diphtheria; Hep, hepatitis.