Table 1.

Comparison of Ensembl and Manual Gene Annotations of the Region

Match type	Sensitivitya	Specificitya
Gene level	0.94	0.83
Transcript level	0.75	0.72
Annotated exons covered completely: all exons	0.76	0.74
Annotated exons covered completely: coding exons	0.90	0.75
Annotated exons with exact matches at boundaries: all exons	0.63	0.57
Annotated exons with exact matches at boundaries: coding exons	0.85	0.71

^aCalculations of sensitivity and specificity represent the success of Ensembl in predicting genes identified by our manual annotation process. Thus, a specificity of 0.83 indicates that 83% of positives in the Ensembl process are true positives by our criteria.