TABLE 1.
Proteins involved in duramycin biosynthesis
| Proteins | No. of residues | Putative annotation | Proposed function(s) in duramycin biosynthesis |
|---|---|---|---|
| DurA | 77 | Structural gene | Precursor peptide |
| DurM | 1,083 | Class II lanthipeptide synthetase | Dehydration of Ser/Thr and cyclization of Dha/Dhb with Cys |
| DurX | 328 | Non-heme Fe(II)-dependent hydroxylase | Hydroxylation of Asp15 |
| DurN | 119 | Hypothetical protein | Formation of lysinoalanine ring |
| Durorf6 | 119 | Hypothetical protein | Unknown |
| Durorf5 | 185 | Hypothetical protein | Unknown |
| Durorf4 | 190 | Putative TetR transcriptional regulator | Pathway regulation |
| Durorf3 | 288 | EamA-like transporter family/permease of the drug/metabolite transporter superfamily | Secretion and/or self-resistance |
| DurT | 352 | Putative ABC transporter | Secretion and/or self-resistance |
| DurH | 290 | Putative ABC transporter | Secretion and/or self-resistance |
| DurY | 340 | Hypothetical protein | Unknown |
| DurZ | 208 | Pfam UPF0029 family | Unknown |