TABLE 1.
Correlations of different functional activities of MAbs
| Comparison | No. of MAbs compared | R2 | Pa |
|---|---|---|---|
| Binding by FACS (without CD4) vs binding by FACS (with CD4) | 37 | 0.056 | 0.157 |
| Binding by FACS (without CD4) vs cytotoxicity of IT (without CD4) | 37 | 0.072 | 0.107 |
| Binding by FACS (with CD4) vs cytotoxicity of IT (with CD4) | 37 | 0.082 | 0.085 |
| Binding by FACS (without CD4) vs neutralization (cell free) | 37 | 0.451 | <0.0001 |
| Binding by FACS (with CD4) vs neutralization (cell free) | 37 | 0.066 | 0.124 |
| Binding by FACS (without CD4) vs neutralization (cell associated) | 24 | 0.462 | 0.0003 |
| Binding by FACS (with CD4) vs neutralization (cell associated) | 24 | 0.013 | 0.59 |
| Cytotoxicity of IT (without CD4) vs cytotoxicity (with CD4) | 37 | 0.156 | 0.015 |
| Cytotoxicity of IT (without CD4) vs neutralization (cell free) | 37 | 0.003 | 0.734 |
| Cytotoxicity of IT (without CD4) vs neutralization (cell associated) | 24 | 0.013 | 0.594 |
| Cytotoxicity of IT (with CD4) vs neutralization (cell free) | 37 | 0.034 | 0.276 |
| Cytotoxicity of IT (with CD4) vs neutralization (cell associated) | 24 | 0.028 | 0.438 |
| Neutralization (cell free) vs neutralization (cell associated) | 24 | 0.644 | <0.0001 |
a
The P values, determined by Pearson's correlation, are not corrected for multiple comparisons. P values in bold are those that remained statistically significant after correction for multiple hypothesis testing via the use of both stringent (Bonferroni correction) and more lenient (Benjamini-Hochberg false discovery rate) criteria.