FIG 1.

Crystal structure of the fifth scavenger receptor cysteine-rich domain (SRCR5) from porcine CD163 (pCD163). (A) Schematic diagram of pCD163 architecture. pCD163 consists of nine SRCR domains (1 to 9), two proline-serine-threonine (PST)-rich motifs (I and II), a transmembrane (TM) domain, and a cytoplasmic tail. (B) Cartoon diagrams of pCD163 SRCR5 represented in the 180° rotation. The β-strands from β1 to β7 are colored in blue, two helices (α1 and α2) are in violet, and the loop regions are in cyan. The N terminus and the C terminus are also labeled. (C) Ribbon diagrams of pCD163 SRCR5 showing the disulfide bonds represented in the 180° rotation. The disulfide bonds are colored in yellow and the bridged cysteines are labeled.