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. 2017 Jan 19;7:40737. doi: 10.1038/srep40737

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Copyright © 2017, The Author(s)

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(a) Variant frequency of 20 somatic tumour variants identified by targeted capture sequencing (upper 11 specific to the original CRC primary [P] and liver metastasis [M]; lower 9 specific to second cholangiocarcinoma [C]) as assayed by a patient-specific multiplex amplicon assay in tumour tissue DNA. (b) ctDNA variant fraction over multiple timepoints post-primary surgery. The 11 CRC primary/metastasis variants (upper panel, red) and 9 cholangiocarcinoma variants (lower, orange) are plotted separately. Each line refers to a separate variant. E1: detection of liver lesion. E2: surgery to remove second primary. E3: clinical detection of a lung metastasis by CT scan.