Figure 1. The schematic diagrams of ClfA and its derivatives.

Residues 1–40 comprises the N-terminal signal sequence (S), followed by the A domain which contains three independently folded subdomains, N1, N2 and N3. The A domain is linked by a flexible SD repeat region (R) which links it to the C-terminal cell wall (W) and membrane-spanning (M) region. The M region contains the LPXTG motif.