Fig. 1.

Schematic diagram depicting the two-step self-assembly of membrane-soluble protein segments in micelles. The designed peptides are extremely hydrophobic, are only minimally soluble in water, and partition readily into micelles forming α-helices. One face of the helix exposes a string of hexafluoroleucine residues, shown in space-filling representation that promotes the formation of higher order aggregates. Gray, C; red, O; blue, N; green, F; purple, backbone. Only the backbone (depicted as a helix) and the core packing residues are shown for clarity.