Figure 2. Multiple KSHV miRNA targets regulate STAT3 activity.

Protein network analysis performed with validated miRNA targets validated in Fig. 1 using MetaCore reveals the existence of an interaction network centering on STAT3. Green arrows indicate positive regulation of STAT3 by the indicated protein while red arrows indicate inhibition. STAT3, itself a KSHV miRNA target, can be activated by indicated miRNA targets (e.g. IRAK1, MET). Several downstream targets of STAT3 can also be repressed by KSHV miRNAs. The name of the miRNA targeting the mRNA identified either in Fig. 1 (red) or from RT-qPCR assays (blue) are given on top of the target.