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. Author manuscript; available in PMC: 2017 Jan 19.
Published in final edited form as: Leukemia. 2015 Dec 21;30(5):1025–1032. doi: 10.1038/leu.2015.346

Figure 4. Treating FLT3/ITD blasts with a FLT3 inhibitor, a DNMT inhibitor, or both simultaneously induces differentiation.

Figure 4

Figure 4

FLT3/ITD primary blasts co-cultured on stroma were treated with drug at the specified concentrations. Cells were harvested on Day 12 after starting drug treatment, stained for the cell-surface markers CD34, CD117, and CD11b, and analyzed via flow cytometry (A). The remaining cells were lysed and analyzed via immunoblotting (B).