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. 2017 Jan 19;7:40929. doi: 10.1038/srep40929

Figure 1. LKB1 promotes actin stress fibers in a farnesylation-dependent manner.

Figure 1

(a) Schematic showing HeLa cells that were transfected to express GFP-tagged: wildtype LKB1, a C430S mutation to disrupt farnesylation, a K78I kinase dead mutation, a double mutation with both K78I and C430S, the C-terminal domain (CTD) alone, or the CTD alone with a C430S mutation. (b) Immunofluorescent images of HeLa cells transfected with GFP-LKB1 and stained with phalloidin-555. (c) The percentage of cells containing lateral stress fibers was quantified 24 hours after transfection. Significance was measured between comparisons using a 2-tailed Chi-squared analysis with a p-value of 0.05, where ****p ≤ 0.0001. Scale bar: 10 μm.