Table 3.
SD change in average arterial distensibility per 1 SD change in exposure (95% CI) (n = 3366) | ||||||||
---|---|---|---|---|---|---|---|---|
Exposure | Model 1 | p Value | Model 2 | p Value | Model 3 | p Value | Model 3 + cIMT | p Value |
Total hip BMD | 0.037 (0.003, 0.071) | 0.031 | 0.005 (–0.029, 0.039) | 0.769 | 0.034 (–0.003, 0.072) | 0.072 | 0.021 (–0.016, 0.057) | 0.270 |
Femoral neck BMD | 0.077 (0.043, 0.110) | <0.001 | 0.041 (0.007, 0.075) | 0.017 | 0.054 (0.018, 0.091) | 0.004 | 0.042 (0.007, 0.078) | 0.020 |
Trochanter BMD | 0.029 (–0.004, 0.063) | 0.090 | 0.007 (–0.026, 0.040) | 0.670 | 0.032 (–0.006, 0.069) | 0.097 | 0.016 (–0.020, 0.053) | 0.376 |
CSMI | 0.094 (0.060, 0.127) | <0.001 | 0.084 (0.052, 0.117) | <0.001 | 0.068 (0.028, 0.108) | 0.001 | 0.057 (0.018, 0.096) | 0.004 |
Total body BMD | 0.074 (0.041, 0.107) | <0.001 | 0.040 (0.007, 0.073) | 0.019 | 0.062 (0.021, 0.102) | 0.003 | 0.046 (0.007, 0.086) | 0.022 |
Total body BA | 0.094 (0.060, 0.127) | <0.001 | 0.071 (0.038, 0.104) | <0.001 | 0.121 (0.070, 0.173) | <0.001 | 0.111 (0.061, 0.161) | <0.001 |
Total body BMC | 0.096 (0.062, 0.129) | <0.001 | 0.066 (0.030, 0.099) | <0.001 | 0.113 (0.064, 0.162) | <0.001 | 0.097 (0.049, 0.145) | <0.001 |
aBMC | 0.067 (–0.025, 0.158) | 0.152 | 0.0004 (–0.091, .090) | 0.993 | 0.051 (–0.046, 0.154) | 0.293 | 0.021 (–0.077, 0.118) | 0.677 |
CI = confidence interval; BMD = bone mineral density; CSMI = cross‐sectional moment of inertia (cm4); BA = bone area; BMC = bone mineral content; aBMC = area‐adjusted total body bone mineral content.
Table shows results of linear regression analysis between hip and total body DXA measurements and arterial distensibility in 3366 individuals. Results are standard deviation change in arterial distensibility per standard deviation increase in exposure (95% confidence intervals) and p value. Model 1 = unadjusted analysis; model 2 = adjustment for age; model 3 = model 2 plus additional adjustment for height, lean mass, fat mass, menopause, smoking, hormone replacement, calcium and/or vitamin D supplement use, and education.