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. 2017 Jan 19;18:4. doi: 10.1186/s13059-016-1137-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Host transcriptional responses in acute EBOV infection. a Venn diagram representing genes that are differentially expressed from control to fatal (blue) and control to survivor (red). Shared genes are shown in magenta. b Histogram illustrating genes increased in abundance in different functional groups. Genes significantly increased in abundance in fatal only (red), survival only (green) or in both (blue) are shown. c Heatmap of pathway upregulation intensity calculated by Ingenuity Pathway Analysis (IPA) for acute-fatal to convalescent control (F/C), acute-survivor to convalescent control (S/C) and acute-fatal to acute-survivor (F/S). Stars within boxes represent calculated p value significance of increased abundance (* < 0.05, ** < 10^–3, *** < 10^–6). d Spider plot of the z scores from the IPA. Increased abundance in fatal to control is in red, survival to control in green