Table 1.

Summary of Reported Cases of Pure Form Pancreatic-Type Acinar Cell Carcinomas Arising in the Stomach

Case No.	Author, year.reference	Age/Sex	Site	Size (cm)	Initial diagnosis	Gross finding	Mitosis	Immunohistochemical staining	Therapeutic operation	Ectopic pancreatic tissue	Assumed origin	Metastasis	Outcome
1	Sun and Wasserman, 2004.[4]	86/F	antrum	5.0	PDAp	exophytic polypoid mass with ulcer	0-3/ HPF	trypsin +, chymotrypsin +, A1AT f+, A1ACT f+, CD56 -, Syn -, Cg -, gastrin -	partial gastrectomy	absence	pure gastric form	absence	NM
2	Mizuno et al., 2007.[3]	73/M	pylorus	7.6	GIST or lymphomac, IIBp	submucosal mass invading pancreatic head	NM	A1AT +	pancreatico-duodenectomy	absence	pure form	LN metastasis	liver metastasis at 7 months, alive after 11 months
3	Ambrosini-Spaltro et al., 2009.[1]	52/M	antrum	4.0	PDAp	ulcerated mass	low mitotic index	A1AT +, Cg -, Syn -, gastrin -	subtotal gastrectomy	presence by pancreatic metaplasia	pancreatic metaplasia	absence	NM
4	Coyne, 2012.[2]	77/F	fundus	4.5	PDAp	exophytic polypoid mass with ulcer	3/10 HPF	trypsin +, A1AT +, CD56 f+, Syn w+, Cg -, serotonin -, insulin -, glucagon -	partial gastrectomy	absence	pure gastric form	absence	died from complications after 1 month
5	Yonenaga et al., case 2, 2016.[5]	63/M	antrum	6.5	PDAp	Borrmann type-2	15/10 HPF	chymotrypsin +, A1ACT +, Cg f+, Syn f+, insulin -, glucagon -, gastrin -, somatostatin -	autopsy	absence	pure gastric form	liver	died from coexisting advanced PaDA after 5 months
6	Present case, 2016	54/M	cardia	2.7	GIST or lymphomac, IIBp	exophytic polypoid mass	1/10 HPF	A1AT +, A1ACT +, CD56 w+, DOG1 w+, Syn -, Cg -, TTF-1 -, CD34 -, c-Kit -	laparoscopic wedge resection	absence	pure gastric form	absence	alive without disease after 33 months

Abbreviations: M male, F female, PDA poorly differentiated adenocarcinoma, HPF high power field, NM not mentioned, GIST gastrointestinal stromal tumor, A1AT α1-antitrypsin, A1ACT α1-antichymotrypsin, Syn synaptophysin, Cg chromogranin, TTF-1 thyroid transcription factor 1, ^p pathologic diagnosis in endoscopic biopsy before the therapeutic operation; ^c clinical diagnosis before therapeutic operation; IIB inconclusive initial biopsy, LN lymph node, PaDA pancreatic ductal adenocarcinoma, + positive, f+ focally positive, w+ weakly positive, − negative