Table 2.
6-min walk test at baseline and at end of the study for all participants
| L-Carnitine-combination | L-Carnitine | Placebo | P ValueΔ | P Value¤ | |
|---|---|---|---|---|---|
| Mean + SD (n) Within Group P Value |
Mean + SD (n) Within Group P Value |
Mean + SD (n) Within Group P Value |
|||
| Meters Walked in Six Minutes (m) | |||||
| Baseline (Week 0) | 432 ± 109 (14) | 458 ± 127 (11) | 526 ± 80 (14) | – | – |
| Visit 2 (Week 8) | 462 ± 113 (14) | 444 ± 119 (11) | 530 ± 100 (14) | – | – |
| Change from Baseline to Week 8 | 30 ± 70 (14) P = 0.126 |
−14 ± 107 (11) P = 0.617 |
3 ± 69 (14) P = 0.704 |
0. 292 | 0.856 |
| Out of Breath Score Before Walking | |||||
| Baseline (Week 0) | 0.21 ± 0.80 (14) | 0.091 ± 0.302 (11) | 0.00 ± 0.00 (14) | – | – |
| Visit 2 (Week 8) | 0.036 ± 0.134 (14) | 0.045 ± 0.151 (11) | 0.000 ± 0.000 (14) | – | – |
| Change from Baseline to Week 8 | −0.18 ± 0.67 (14) P = 1.000‡ |
−0.14 ± 0.64 (11) P = 0.590‡ |
0.00 ± 0.00 (14) P = 1.000‡ |
0. 295 | 0.353 |
| Out of Breath Score After Walking | |||||
| Baseline (Week 0) | 1.07 ± 2.16 (14) | 0.55 ± 0.79 (11) | 1.04 ± 0.91 (14) | – | – |
| Visit 2 (Week 8) | 1.00 ± 1.79 (14) | 0.41 ± 0.58 (11) | 0.61 ± 0.56 (14) | – | – |
| Change from Baseline to Week 8 | −0.07 ± 0.87 (14) P = 0.730‡ |
−0.14 ± 0.64 (11) P = 0.590‡ |
−0.43 ± 0.70 (14) P = 0.044‡ |
0. 234 | 0.222 |
| Change in Out of Breath Score After Walking | |||||
| Baseline (Week 0) | 0.86 ± 1.60 (14) | 0.45 ± 0.65 (11) | 1.04 ± 0.91 (14) | – | – |
| Visit 2 (Week 8) | 0.96 ± 1.70 (14) | 0.36 ± 0.45 (11) | 0.61 ± 0.56 (14) | – | – |
| Change from Baseline to Week 8 | 0.11 ± 0.68 (14) P = 0.792‡ |
−0.09 ± 0.66 (11) P = 0.792‡ |
−0.43 ± 0.70 (14) P = 0.044‡ |
0. 175 | 0.069 |
| Fatigue Score Before Walking | |||||
| Baseline (Week 0) | 0.21 ± 0.54 (14) | 0.50 ± 1.02 (11) | 0.54 ± 0.93 (14) | – | – |
| Visit 2 (Week 8) | 0.25 ± 0.80 (14) | 0.18 ± 0.60 (11) | 0.39 ± 0.92 (14) | – | – |
| Change from Baseline to Week 8 | 0.04 ± 0.95 (14) P = 0.854‡ |
−0.32 ± 1.27 (11) P = 0.461‡ |
−0.14 ± 0.57 (14) P = 0.387‡ |
0. 853 | 0.893 |
| Fatigue Score After Walking | |||||
| Baseline (Week 0) | 0.64 ± 1.36 (14) | 0.82 ± 1.03 (11) | 0.82 ± 0.91 (14) | – | – |
| Visit 2 (Week 8) | 0.93 ± 1.25 (14) | 0.45 ± 0.88 (11) | 0.61 ± 0.86 (14) | – | – |
| Change from Baseline to Week 8 | 0.29 ± 1.17 (14) P = 0.394‡ |
−0.36 ± 1.38 (11) P = 0.348‡ |
−0.21 ± 0.64 (14) P = 0.266‡ |
0. 800 | 0.154 |
| Change in Fatigue Score After Walking | |||||
| Baseline (Week 0) | 0.43 ± 1.33 (14) | 0.32 ± 0.64 (11) | 0.29 ± 0.64 (14) | – | – |
| Visit 2 (Week 8) | 0.68 ± 1.05 (14) | 0.273 ± 0.344 (11) | 0.21 ± 0.26 (14) | – | – |
| Change from Baseline to Week 8 | 0.25 ± 1.03 (14) P = 0.341‡ |
−0.05 ± 0.65 (11) P = 1.000‡ |
−0.07 ± 0.68 (14) P = 0.660‡ |
0. 729 | 0.201 |
N number, SD standard deviation
ΔBetween-group comparisons for placebo and L-Carnitine were made using the Mann-Whitney U test
¤Between-group comparisons for placebo and L-Carnitine-Combination were made using the Mann-Whitney U test
‡Within-group comparisons were made using the signed-rank test
Probability values P ≤ 0.05 are statistically significant
The bold data represents a significant P value (P>0.05)