Table 2.
miRNA profiles of the RA patients with or without ILD
| ILD(+)RA | UIP(+)RA | NSIP(+)RA | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| miRNA | ILD(+)RA | UIP(+)RA | NSIP(+)RA | ILD(−)RA | P | FDR Q | P | FDR Q | P | FDR Q |
| hsa-miR-29c-3p | 28.7 (92.4) | 45.9 (121.6) | 6.7 (10.4) | 2.9 (2.5) | 0.1772 | 0.6025 | 0.0499 | 0.1698 | 0.9334 | 0.9334 |
| hsa-miR-154-5p | 17.9 (59.1) | 24.6 (76.8) | 9.3 (21.3) | 2.0 (2.8) | 0.9238 | 0.9815 | 0.5331 | 0.7294 | 0.3604 | 0.7416 |
| hsa-miR-543 | 11.0 (35.9) | 14.8 (46.6) | 6.1 (13.9) | 1.4 (1.4) | 0.4386 | 0.6213 | 0.8633 | 0.9173 | 0.1145 | 0.6099 |
| hsa-miR-214-5p | 8.1 (28.2) | 13.6 (37.0) | 1.0 (3.2) | 0.2 (0.9) | 0.0156 | 0.1322 | 0.0076 | 0.0643 | 0.1697 | 0.6099 |
| hsa-miR-382-3p | 10.9 (41.5) | 14.8 (52.9) | 5.8 (19.9) | 0.9 (1.7) | 0.4279 | 0.6213 | 0.9473 | 0.9473 | 0.1794 | 0.6099 |
| hsa-let-7g-3p | 29.1 (107.3) | 50.3 (141.1) | 1.9 (3.7) | 3.3 (5.3) | 0.6098 | 0.7974 | 0.5578 | 0.7294 | 0.1095 | 0.6099 |
| hsa-miR-9-5p | 5.8 (18.5) | 9.1 (24.2) | 1.5 (4.2) | 0.9 (2.6) | 0.8510 | 0.9815 | 0.7724 | 0.8753 | 0.4947 | 0.7416 |
| hsa-miR-370-3p | 12.2 (57.4) | 18.2 (76.3) | 4.5 (11.1) | 0.3 (0.4) | 0.8766 | 0.9815 | 0.3648 | 0.6202 | 0.4734 | 0.7416 |
| hsa-miR-221-5p | 17.1 (53.1) | 26.6 (68.7) | 5.0 (16.6) | 0.7 (1.2) | 0.3227 | 0.6213 | 0.0461 | 0.1698 | 0.5235 | 0.7416 |
| hsa-miR-483-5p | 80.7 (331.8) | 130.5 (440.8) | 16.6 (24.4) | 14.3 (33.9) | 0.2827 | 0.6213 | 0.2330 | 0.4951 | 0.6161 | 0.7888 |
| hsa-miR-7-5p | 56.2 (260.4) | 91.1 (347.0) | 11.5 (19.9) | 4.7 (11.8) | 0.0362 | 0.2049 | 0.0275 | 0.1559 | 0.2616 | 0.6571 |
| hsa-miR-376b-3p | 14.6 (48.8) | 19.0 (63.4) | 9.0 (19.3) | 1.1 (1.4) | 0.3718 | 0.6213 | 0.2621 | 0.4951 | 0.7915 | 0.8751 |
| hsa-miR-487b-3p | 12.7 (56.4) | 19.1 (75.0) | 4.4 (10.2) | 0.5 (0.7) | 0.2437 | 0.6213 | 0.1181 | 0.2868 | 0.8237 | 0.8751 |
| hsa-let-7f-1-3p | 24.9 (114.7) | 39.8 (153.0) | 5.7 (9.4) | 2.6 (2.8) | 0.9893 | 0.9893 | 0.6856 | 0.8326 | 0.6496 | 0.7888 |
| hsa-miR-500a-5p | 55.8 (230.6) | 94.7 (305.3) | 5.7 (12.3) | 1.7 (4.6) | 0.3744 | 0.6213 | 0.4566 | 0.7056 | 0.4823 | 0.7416 |
| hsa-miR-582-5p | 144.8 (288.5) | 208.4 (360.8) | 63.0 (124.4) | 31.5 (60.5) | 0.0693 | 0.2946 | 0.0705 | 0.1998 | 0.2706 | 0.6571 |
| miRNA Index (214, 7) | 0.122 (0.332) | 0.202 (0.430) | 0.019 (0.034) | 0.006 (0.013) | 0.0010 | 0.0162 | 0.0005 | 0.0093 | 0.0732 | 0.6099 |
Average values of each group are shown. Standard deviations are shown in parenthesis. Differences were tested by Mann-Whitney’s U test. To correct for multiple testing, the false discovery rate Q-value was calculated
RA rheumatoid arthritis, ILD interstitial lung disease, UIP Usual interstitial pneumonia, NSIP Nonspecific interstitial pneumonia, ILD(+)RA RA with ILD, UIP(+)RA RA with ILD of UIP pattern, NSIP(+)RA RA with ILD of NSIP pattern, ILD(−)RA RA without ILD