Table 3.
Baseline and 8 week imaging parameters (median and interquartile range, IQR) for CR/VGPR and ≤PR patients. Temporal changes in each group were assessed using Wilcoxon matched‐pairs signed rank test and significance defined as P < 0·05
| Scan | Median eTV (IQR) | Median ER (IQR) | Median ADC (IQR) | Median sFF (IQR) | |
|---|---|---|---|---|---|
|
CR/VGPR (n = 12) |
Baseline | 0·24 (0·15–0·86) | 114·7 (97·2–190·2) | 0·79 (0·66–1·26) | 0·24 (0·20–0·27) |
| 8 weeks | 0·13 (0·10–0·47)a | 140·6 (88·4–184·2) | 1·50 (0·88–1·83)a | 0·44 (0·37–0·63)a | |
|
≤ PR (n = 9) |
Baseline | 0·17 (0·08–0·87) | 84·8 (73·6–121·9) | 0·66 (0·52–0·87) | 0·40 (0·29–0·54) |
| 8 weeks | 0·08 (0·04–0·59)a | 127·8 (56·0–194·5) | 0·75 (0·51–1·27)a | 0·48 (0·32–0·60)a |
CR, complete response; VGPR, very good partial response; PR, partial response; eTV, estimated total tumour volume; ER, enhancement ratio; ADC, mean apparent diffusion coefficient; sFF, signal fat fraction; IQR, interquartile range.
a
Significant change (P < 0·05) compared with baseline scan.