Fig. 3.

Antibodies isolated from adult donors recognize six antigenic sites spanning the surface of preF. (A) Structure of RSV preF with one protomer shown as a ribbon colored by antigenic site. (B) Percentage of antibodies targeting each antigenic site within each donor repertoire. The antigenic sites recognized by 215 antibodies with higher than 2 nM affinity for preF were mapped using a combination of antibody binning and patch variant mutational analysis. (C) Percentage of preF-specific antibodies targeting each antigenic site.