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Effect of nicotine on endothelial progenitor cell senescence, determined by β-gal-positive cells in the (A) C-1, (B) N-1, (C) C-6 and (D) N-6 groups. (E) Statistical analysis of β-gal-positive cells *P<0.05 vs. C-1 M group; **P<0.05 vs. C-6 M group. Cells were extracted from 3 mice. C, control; M, month(s); N, nicotine-treated.
