Table III.
Achaete-scute complex-like (ASCL) 2 expression in cancer.
| Gene | Cancer | Subtype | Case no. | Change expression | P-value (cancer/normal) | t-test (cancer/normal) | Fold change (cancer/normal) | % Gene ranking | Database reference |
|---|---|---|---|---|---|---|---|---|---|
| ASCL2 | Breast | Invasive ductal breast carcinoma | 2136 | ↑ | 4.39E-72 | 23.54 | 2.14 | 582 (top 4%) | (81) |
| Invasive lobular breast carcinoma | 2136 | ↑ | 1.42E-26 | 12.34 | 2.31 | 1,080 (top 6%) | (81) | ||
| Invasive ductal and invasive lobular breast carcinoma | 2136 | ↑ | 4.26E-16 | 9.38 | 2.05 | 1,794 (top 10%) | (81) | ||
| Medullary breast carcinoma | 2136 | ↑ | 5.67E-12 | 9.87 | 2.84 | 449 (top 3%) | (81) | ||
| Breast carcinoma | 2136 | ↑ | 1.88E-4 | 4.60 | 1.67 | 1,375 (top 8%) | (81) | ||
| Invasive breast carcinoma stroma | 59 | ↑ | 1.49E-14 | 11.34 | 3.91 | 1,068 (top 6%) | (82) | ||
| Ductal breast carcinoma in situ | 63 | ↑ | 0.009 | 4.18 | 14.91 | 289 (top 2%) | (83) | ||
| Colorectal | Rectal adenocarcinoma | 130 | ↑ | 8.24E-52 | 26.18 | 9.71 | 10 (top 1%) | (84) | |
| Colon adenocarcinoma | 237 | ↑ | 3.20E-27 | 15.78 | 6.53 | 125 (top 1%) | (98) | ||
| Rectal adenocarcinoma | 237 | ↑ | 3.36E-27 | 16.38 | 8.77 | 66 (top 1%) | (98) | ||
| Cecum adenocarcinoma | 237 | ↑ | 1.97E-12 | 10.84 | 6.28 | 396 (top 2%) | (98) | ||
| Rectosigmoid adenocarcinoma | 237 | ↑ | 2.31E-8 | 18.07 | 6.50 | 206 (top 2%) | (98) | ||
| Colon adenocarcinoma | 105 | ↑ | 1.36E-26 | 23.35 | 8.96 | 2 (top 1%) | (85) | ||
| Cecum adenocarcinoma | 105 | ↑ | 8.03E-8 | 8.60 | 7.15 | 274 (top 2%) | (85) | ||
| Rectal adenocarcinoma | 105 | ↑ | 1.02E-6 | 12.69 | 6.64 | 50 (top 1%) | (85) | ||
| Rectosigmoid adenocarcinoma | 105 | ↑ | 1.87E-4 | 5.47 | 6.95 | 1,632 (top 9%) | (85) | ||
| Colorectal carcinoma | 82 | ↑ | 3.55E-19 | 15.43 | 24.81 | 46 (top 1%) | (86) | ||
| Colorectal adenocarcinoma | 105 | ↑ | 2.63E-18 | 12.56 | 6.13 | 62 (top %) | (87) | ||
| Colorectal carcinoma | 105 | ↑ | 1.72E-13 | 9.40 | 5.64 | 100 (top 1%) | (87) | ||
| Colon adenoma | 64 | ↑ | 5.60E-18 | 15.27 | 8.94 | 101 (top 1%) | (77) | ||
| Rectal adenoma | 64 | ↑ | 3.80E-5 | 7.84 | 17.43 | 1,580 (top 9%) | (77) | ||
| Colon adenoma | 40 | ↑ | 1.80E-11 | 21.19 | 31.35 | 17 (top 1%) | (87) | ||
| Colon carcinoma | 40 | ↑ | 1.05E-10 | 20.53 | 24.23 | 162 (top 1%) | (87) | ||
| Colon adenoma epithelia | 40 | ↑ | 5.68E-8 | 10.74 | 14.14 | 233 (top 2%) | (87) | ||
| Colon carcinoma epithelia | 40 | ↑ | 3.60E-7 | 10.42 | 10.79 | 914 (top 5%) | (87) | ||
| Lung | Squamous cell lung carcinoma | 156 | ↑ | 7.81E-8 | 6.48 | 1.84 | 1,660 (top 9%) | (88) | |
| Squamous cell lung carcinoma | 203 | ↑ | 0.004 | 2.79 | 3.63 | 639 (top 8%) | (59) | ||
| Gastric | Diffuse gastric adenocarcinoma | 90 | ↑ | 1.74E-6 | 5.35 | 3.40 | 348 (top 2%) | (66) | |
| Gastric intestinal-type adenocarcinoma | 90 | ↑ | 3.01E-6 | 5.68 | 4.17 | 131 (top 1%) | (66) | ||
| Gastric mixed adenocarcinoma | 90 | ↑ | 6.30E-4 | 4.35 | 4.45 | 923 (top 5%) | (66) | ||
| Gastric cancer | 160 | ↑ | 9.27E-6 | 4.43 | 2.35 | 400 (top 3%) | (74) | ||
| Gastrointestinal stromal tumor | 90 | ↓ | 4.59E-4 | −4.91 | −2.59 | 7,733 (top 9%) | (66) | ||
| Lymphoma | Nodular lymphocyte-predominant Hodgkin's lymphoma | 67 | ↑ | 7.61E-5 | 10.55 | 2.65 | 821 (top 5%) | (89) | |
| Head-neck | Nasopharyngeal carcinoma | 41 | ↑ | 5.08E-4 | 3.57 | 1.56 | 1,794 (top 10%) | (90) | |
| Ovarian | Ovarian endometrioid adenocarcinoma | 50 | ↑ | 0.001 | 3.96 | 1.76 | 506 (top 3%) | (91) | |
| Testis | Testicular seminoma | 30 | ↑ | 0.007 | 8.03 | 3.21 | 806 (top 6%) | (92) | |
| Prostate | Prostate carcinoma | 21 | ↓ | 2.12E-4 | −4.26 | −1.91 | 279 (top 2%) | (93) | |
| Brain | Oligodendroglioma | 42 | ↓ | 4.42E-4 | −6.05 | −1.73 | 689 (top 9%) | (58) | |
| Melanoma | Cutaneous melanoma | 87 | ↓ | 6.22E-4 | −4.70 | −6.74 | 927 (top 5%) | (80) |