Table II.
SNP sequencing results.
| Gene type | Locus mutation | Gene frequency of minor allele | Mutation rate [case (%)] | CR+PR group (n=45) | SD+PD group (n=23) | χ2 | P-value |
|---|---|---|---|---|---|---|---|
| VEGFR1 | |||||||
| rs664393 | G>A | 0.244 | 13 (19.1) | 9 (20.0) | 4 (17.4) | 0.000 | 1.000 |
| VEGFR2 | |||||||
| rsl870377 | A>T | 0.467 | 31 (45.6) | 15 (33.3) | 16 (69.6) | 8.055 | 0.005 |
| rs7667298 | C>T | 0.284 | 15 (22.1) | 8 (17.8) | 7 (30.4) | 1.418 | 0.234 |
| VEGFR3 | |||||||
| rs448012 | C>G | 0.483 | 29 (42.6) | 14 (31.1) | 15 (65.2) | 7.239 | 0.007 |
| rs72816988 | G>A | 0.079 | 7 (10.3) | 3 (6.7) | 4 (17.4) | 0.912 | 0.340 |
SNPs, single nucleotide polymorphisms; CR, complete response; PR, partial response; SD, stable disease; PD, progression of disease.