Table 1.
Binding affinities of N-phenylpropyl-N´-substituted piperazines for σ1 and σ2 sigma receptors.
| N’-Piperazine Substitution | σ1 (nM) | σ2 (nM) | Citation | |
|---|---|---|---|---|
| SA4503 | 3,4-dimethoxyphenethyl | 4.63 (±0.21) | 63.09 (±4.33) | Lever et al., 2006 |
| YZ-185 | 3-methoxyphenethyl | 1.4 (±0.2) | 10.2 (±0.5) | Matsumoto et al., 2004 |
| YZ-067 | 4-methoxyphenethyl | 1.3 (±0.3) | 28.6 (±1.9) | Matsumoto et al., 2004 |
| Nahas-3h | 4-methoxybenzyl | 0.76 (±0.07) | 32.8 (±2.93) | Nahas et al., 2008 |
| Methamphetamine | 2,160 (±0.25) | 46,670 (±10.34) |
Nguyen et al., 2005 |
Values represent mean (± S.E.M.) Ki values as reported by the citations in the table.