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Gray value of HIF-1α in articular cartilage is correlated with Mankin score of osteoarthritis (Spearman's ρ=−0.967; P<0.001). Osteoarthritis changes were classified histomorphologically, using the Mankin grading system. Spearman's correlation and linear regression analyses were used to determine whether the gray value of HIF-1α in articular cartilage correlated with the Mankin score of osteoarthritis. HIF-1α, hypoxia-inducible factor 1α.
