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. 2016 Nov 23;13(1):329–338. doi: 10.3892/ol.2016.5423

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Silencing of DNA methyltransferase 3A (DNMT3A) suppresses lung cancer cell growth and induces S-phase arrest and cell apoptosis in A549 cells. (A) Reverse transcription-quantitative polymerase chain reaction analysis was performed to determine the expression of DNMT3A following transfection of siDNMT3A. (B-E) MTT assay was performed and clone formation, cell cycle and cell apoptosis were assessed to determine the effects of siDNMT3A on the growth and apoptosis of A549 cells. (F) Analysis of expression of DNMT3A/AKT signaling pathway regulatory proteins in A549 cells at 48 h after knockdown of DNMT3A. β-actin was used as a housekeeping control (*P<0.05, **P<0.01, Student's t-test).