Table III.
Univariate survival analysis by significant prognostic factors using the Kaplan-Meier model.
| Patients not transformed into malignancy | Patients transformed into malignancy | ||||||
|---|---|---|---|---|---|---|---|
| Prognostic factors | Patients, n | N | % | N | % | Median survival time, months (95% CI) | P-value |
| ALDH1 expression | 0.006 | ||||||
| Negative | 31 | 21 | 68 | 10 | 32 | 120 (59–125) | |
| Positive | 48 | 21 | 44 | 27 | 56 | 51 (34–85) | |
| Podoplanin expression | 0.010 | ||||||
| Negative | 26 | 20 | 77 | 6 | 23 | 102 (45-~)a | |
| Positive | 53 | 22 | 42 | 31 | 58 | 55 (36–85) | |
| Dysplasia | 0.012 | ||||||
| LGD | 27 | 17 | 63 | 10 | 37 | 102 (69-~)a | |
| HGD | 52 | 25 | 48 | 27 | 52 | 51 (36–69) | |
| Co-expression of proteins (ALDH1 and podoplanin) | <0.001 | ||||||
| Absent | 44 | 30 | 68 | 14 | 32 | 102 (69–125) | |
| Present | 35 | 12 | 34 | 23 | 66 | 38 (13–55) | |
a
Upper limit of CI cannot be estimated due to fewer events. CI, confidence interval; ALDH1, aldehyde dehydrogenase 1; LGD, low-grade dysplasia; HGD, high-grade dysplasia.