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. 2016 Nov 30;56(3):177–184. doi: 10.1002/gcc.22420

Table 3.

Individual miRNA Variants Exhibiting Marginal Positive Associationa in Cases Versus Controlsb

Signed kernel P value Minimum FDR Q‐valueg
miRNA Chromosome POSc REFd ALTe All cases (n = 899)f dMMR cases (n = 129)f FCCTX/pMMR linkage cases (n = 229)f Young Onset cases (n = 206)f Unselected cases (n = 335)f pMMR cases (n = 734)f
MIR216A chr2 56216090 A T 0.102 0.142 0.320 0.138 0.117 0.090 0.271
MIR663B chr2 133014587 C T 0.488 0.016 −0.630 −0.665 0.331 0.955 0.271
MIR1258 chr2 180725568 T C 0.519 0.027 0.821 −0.780 0.759 0.787 0.271
MIR4268 chr2 220771223 C T 0.222 0.407 0.064 0.745 0.403 0.230 0.271
MIR4789 chr3 175087408 C T 0.099 −0.525 0.016 0.091 0.224 0.046 0.271
hsa‐mir‐1294 chr5 153726769 A G 0.265 0.241 0.789 0.088 0.459 0.250 0.271
hsa‐mir‐3144 chr6 120336327 C A 0.166 0.643 0.033 0.852 0.191 0.123 0.271
MIR4467 chr7 102111936 G A 0.062 0.289 0.034 0.076 0.289 0.062 0.271
MIR3622A:MIR3622B chr8 27559214 G A 0.104 0.066 0.278 0.117 0.271 0.138 0.271
hsa‐mir‐1302‐7 chr8 142867668 ATGT A 0.022 0.012 0.107 0.026 0.009 0.021 0.271
MIR4669 chr9 137271318 C A 0.008 0.173 0.109 0.003 0.030 0.007 0.271
MIR3689A chr9 137742206 C T 0.050 0.354 0.049 0.248 0.038 0.043 0.271
MIR1908 chr11 61582708 T C 0.841 0.016 −0.636 −0.424 0.885 −0.713 0.271
MIR612 chr11 65211940 C A 0.930 0.745 −0.174 0.043 −0.590 −0.942 0.271
MIR492 chr12 95228286 G C 0.199 0.078 0.077 0.905 0.435 0.284 0.271
hsa‐mir‐300:MIR300 chr14 101507727 C T 0.235 0.778 0.213 0.074 0.619 0.198 0.271
MIR381HG chr14 101513795 C T 0.042 0.138 0.095 0.003 0.305 0.048 0.271
MIR656 chr14 101533093 C T 0.118 0.087 0.115 0.110 0.369 0.119 0.271
MIR4513 chr15 75081078 G A 0.189 0.087 0.314 −0.798 0.095 0.324 0.271
MIR184 chr15 79502168 G T 0.251 0.511 0.479 0.749 0.097 0.336 0.271
MIR1225 chr16 2140262 T TC 0.567 0.047 0.913 −0.988 0.868 0.831 0.271
MIR4520A:MIR4520B chr17 6558808 G A 0.104 0.241 0.279 −0.766 0.012 0.127 0.271
MIR423 chr17 28444183 A C 0.059 0.168 0.833 0.203 0.006 0.088 0.271
MIR4745 chr19 804959 C T 0.718 −0.759 −0.614 0.079 0.941 0.605 0.271
MIR3190:MIR3191 chr19 47730272 A C 0.186 0.811 −0.398 −0.043 0.00008 0.126 0.155
MIR4751 chr19 50436371 G A 0.121 0.092 0.148 0.382 0.243 0.139 0.271
MIR4754 chr19 58898193 C T 0.001 0.164 0.003 0.018 0.00100 0.0005 0.271
MIR3192 chr20 18451325 T C 0.036 0.135 0.085 0.182 0.009 0.036 0.271
hsa‐mir‐941‐3:MIR941‐2:MIR941‐4 chr20 62551298 C T 0.264 0.071 0.567 0.174 0.672 0.445 0.271
MIRLET7BHG chr22 46487011 G A 0.104 0.034 0.159 0.259 0.313 0.123 0.271
a

Marginal evidence defined as sign of the burden statistic multiplied by kernel statistic P value in [0, 0.10].

b

The control group consists of 91 spousal controls and 113 participants with known mismatch repair gene mutations.

c

POS, genomic position.

d

REF, reference allele.

e

ALT, alternate allele.

f

Highlighted (bold) boxes = P value <0.10.

g

FDR, false discovery rate. Minimum FDR Q‐value for each variant. FDR Q‐value was calculated considering all case–control comparisons simultaneously.