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. 2016 Nov 24;13(1):13–21. doi: 10.3892/ol.2016.5431

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Copyright: © Ding et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Roles of L-selectin are similar in lymphocyte homing and the lymphatic metastasis of cancer. The lymphatic metastasis of cancer has a high degree of similarity with lymphocyte homing. PNAds and MRs are ligands of L-selectin for lymphocyte adhesion to (A) HEVs and (B) lymphatic vessels, respectively. The attachment of cancer cells to HEVs and lymphatic vessels has been identified, although the corresponding ligands remain to be elucidated. PNads, peripheral lymph node addressins; HEV, high endothelial venule; MR, mannose receptor.