(A) Mitral regurgitation severity at rest and during peak exercise before and 6 months after percutaneous repair therapy. (B) Pulmonary pressures and cardiac output at rest and peak exercise are improved at 6 months after the therapy. CI, confidence interval; CO, cardiac output; LA, left atrial; MR, mitral regurgitation; SPAP, systolic pulmonary artery pressure. Reproduced from Van de Heyning et al124 with permission.