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. Author manuscript; available in PMC: 2018 Jan 17.
Published in final edited form as: Circulation. 2017 Jan 17;135(3):297–314. doi: 10.1161/CIRCULATIONAHA.116.025260

Figure 6. Prognostic impact of secondary mitral valve regurgitation (MR) at rest and during exercise.

Figure 6

(A) Mortality in heart failure patients with secondary MR at rest follows a graded relationship with respect to MR severity. Severe MR (EROA>20mm2) already implies worse outcome for both ischemic and non-ischemic cardiomyopathy. Adapted from Rossi et al66 and Asgar et al67, with permission. (B) Mortality in patients with deteriorating secondary MR during exercise (EROA increase >13mm2), is increased and similar to patients with severe secondary MR at rest. Reproduced from Lancellotti et al9, with permission.