Table 1. Clinical characteristics of the CLAD Free and Incipient CLAD cohorts.
| CLAD Free Included (n = 8) | CLAD Free Excluded (n = 15) | Incipient CLAD Included (n = 9) | Incipient CLAD Excluded (n = 14) | P-value | |
|---|---|---|---|---|---|
| Sex (%) | 0.52 | ||||
| Male | 3 (38) | 10 (67) | 6 (67) | 9 (64) | |
| Female | 5 (62) | 5 (33) | 3 (33) | 5 (36) | |
| Age at transplant, mean ± SD | 57.3 ± 9.7 | 54.2 ± 9.9 | 57.9 ± 6.6 | 60.7 ± 8.3 | 0.28 |
| Pre-transplant disease (%) | 0.95 | ||||
| COPD | 3 (38) | 5 (33) | 2 (22) | 5 (36) | |
| Restrictive lung disease | 4 (50) | 8 (53) | 6 (67) | 6 (43) | |
| Other | 1 (12) | 2 (13) | 1 (11) | 3 (21) | |
| Type of Transplant (%) | 0.08 | ||||
| Bilateral | 6 (75) | 11 (73) | 9 (100) | 7 (50) | |
| Single | 2 (25) | 4 (37) | 0 (0) | 7 (50) | |
| FEV1% predicted, median (IQR)† | 74 (68–98) | 71 (51–93) | 74 (72–91) | 67 (57–89) | 0.54 |
| FEV1% of baseline, median (IQR)† | 98 (96–100) | 96 (93–100) | 87 (84–95) | 91 (86–96) | 0.006a |
| Months to Sample, median (IQR) | 12.4 (12.2–12.5) | 12.6 (11.7–14.3) | 13.6 (12.3–18.8) | 12.8 (12.4–15.2) | 0.24 |
| RNA Integrity Number, median (IQR) | 7.8 (7.1–8.0) | 4.3 (2.7–5.5) | 8.1 (7.6–9.0) | 4.9 (3.3–5.2) | <0.0001b |
†Characteristics are at the time of sample acquisition.
aComparison of CLAD Free Included vs. Incipient CLAD Included by Mann Whitney P = 0.01.
bComparison of CLAD Free Included vs. Incipient CLAD Included by Mann Whitney P = 0.14.