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. 2017 Jan 19;12(1):e0169496. doi: 10.1371/journal.pone.0169496

Fig 2. Splenic expression of markers of CD4+ T cell subpopulations over the course of chronic L. donovani infection.

Fig 2

RNA was isolated from spleen tissue from uninfected controls (C) and hamsters infected for 7, 14, 21 and 28 days. Gene expression for (A) Th1 (B) Th2 and (C) Treg cells was determined by real time RT-PCR. Fold change was calculated relative to basal gene expression in uninfected baby hamster kidney (BHK) cell line. Figures are representative of at least 3 independent experiments with 3–6 animals per experiment. *p<0.05, **p<0.01, ****p<0.0001. Th1-associated genes indicated by the color red, Th2-associated genes indicated by the color green, Treg-associated genes indicated by the color purple.