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. 2017 Jan 19;12(1):e0169496. doi: 10.1371/journal.pone.0169496

Fig 8. Ex vivo blockade of PD-L2 reduces parasite burden.

Fig 8

Spleen cells from 28-day chronically infected hamsters were cultured with αPD-L2 antibody or isotype control for 48 hours. The parasite burden (18s mRNA expression) and expression of iNOS, IFNγ, Arg1 and IL-10 were determined by real time RT-PCR. Results are expressed as a relative fold-increase of the αPD-L2 antibody or isotype control groups compared to infected splenocytes at 0 hours. Shown is the mean and SEM of two independent experiments with 6 replicates per group.