Table 2. Mass dependence of [Nle14,125I-Tyr40-NH2]Ex-4 biodistribution in nude mice bearing Ins-1E xenografts 1 h p.i.
| Organ | %IA/g # | ||
|---|---|---|---|
| 10 pmol | %IA/g 100 pmol | 10 pmol + irenat | |
| Blood | 3.9±0.2** | 4.1±0.4** | 4.1±0.4** |
| Heart | 1.2±0.2 | 1.1±0.1 | 1.3±0.3 |
| Lung | 12.9±1.1** | 5.5±0.8** | 14.6±2.5** |
| Liver | 1.4±0.1 | 1.5±0.1 | 1.6±0.2 |
| Spleen | 1.5±0.1 | 1.5±0.1 | 1.4±0.1 |
| Pancreas | 22.9±2.2 | 8.4±0.8** | 19.9±5.9 |
| Stomach | 12.2±1.2 | 10.9±0.2* | 5.3±0.9** |
| Intestine | 2.6±0.7 | 1.7±0.1 | 2.1±0.2** |
| Kidney | 7.9±1.1 | 7.5±0.8 | 8.5±1.9 |
| Adrenal | 1.2±0.5 | 0.9±0.2 | 1.2±0.1 |
| Muscle | 0.4±0.1 | 0.4±0.1 | 0.6±0.1 |
| Bone | 0.9±0.1 | 0.9±0.2 | 1.0±0.1 |
| Ins-1E | 56.3±8.1 | 20.3±3.5** | 60.0±22.7 |
| Thyroid a | 1.4±0.1a | 0.1±0.0a** | |
| Tumor-to-blood | 14.4 | 5.0 | 14.6 |
| Tumor-to-muscle | 140.8 | 50.8 | 100.0 |
| Tumor-to-kidney | 7.1 | 2.7 | 7.1 |
| Tumor-to-pancreas | 2.5 | 2.4 | 3.0 |
# Values are mean±standard deviation (n = 3–4).
*p<0.05.
**p<0.01, compared to the 1h / 0.5 pmol group of Table 1 (for the thyroid, comparison is against the 1h / 10pmol group of Table 2).
a Thyroid uptake is reported as %IA/organ. Reason for this is the complicated delineation of the thyroid, which resulted in excision of variable amounts of adjacent tissue upon dissection and concomitantly incorrect values when uptake is reported as %IA/g.