Table 3. Biodistribution of [Nle¹⁴,¹²⁵I-Tyr⁴⁰-NH₂]Ex(9–39) in mice bearing Ins-1E xenografts.

Organ	%IA/g #
	1 ha	1 h–blocked	1 h– 10 pmol	4 h
Blood	4.2±0.5	3.2±0.2	4.4±0.1	2.0±0.4*
Heart	1.3±0.2	0.9±01	1.2±0.0	0.5±0.1*
Lung	13.6±1.0	1.7±0.4**	9.8±0.9*	3.3±1.2**
Liver	3.2±0.5	1.5±0.7*	2.9±0.3	0.9±0.2**
Spleen	1.5±0.2	1.1±0.1	1.7±0.1	0.8±0.1*
Pancreas	17.93±1.41	1.3±0.4**	17.8±2.4	3.6±1.2**
Stomach	11.9±1.6	12.0±0.7	11.2±3.6	5.3±1.9*
Intestine	2.4±0.4	2.2±0.5	3.8±1.9	1.1±0.0*
Kidney	7.6±1.2	4.2±0.2*	7.2±0.6	2.0±0.3**
Adrenal	1.3±0.4	0.6±0.5	1.3±0.1	0.5±0.1*
Muscle	0.7±0.2	0.6±0.0	1.2±0.7	0.6±0.4
Bone	1.2±0.1	1.4±0.6	1.3±0.2	0.8±0.3*
Ins-1E	12.7±4.1	2.6±0.8*	9.5±2.7	1.9±0.5*
Thyroidb	n.d	n.d.	1.3±0.2	n.d.
Tumor-to-Blood	3.1		2.2	1.0
Tumor-to-Muscle	17.8		7.7	3.3
Tumor-to-Kidney	1.7		1.3	1.0
Tumor-to-pancreas	0.7		0.5	0.5

^# Values are mean±standard deviation (n = 3–4).

^a the peptide mass is 0.5 pmol, based on the specific activity of ¹²⁵I^.

^b—thyroid uptake is reported as %IA/organ.

*p<0.05.

**p<0.001, compared to the 1 h group.

n.d.—not determined.