Table 1. Demographics and clinical characteristics of the 75 adults with severe dengue in intensive care units.
| Variables | All (n = 75) | Survivors (n = 44) | Non-survivors (n = 31) | P value |
|---|---|---|---|---|
| Age (years) | 72.3±9.3 | 70.8±8.9 | 74.6±9.4 | 0.070 |
| Male | 46 (61.3) | 32 (72.7) | 14 (45.2) | 0.029 |
| Body weight (kg) | 64.9±12.4 | 67.3±10.7 | 61.6±14.0 | 0.064 |
| Underlying disease | ||||
| Hypertension | 54 (72.0) | 35 (79.5) | 19 (61.3) | 0.117 |
| Diabetes mellitus | 32 (42.7) | 18 (40.9) | 14 (45.2) | 0.814 |
| Chronic kidney disease | 17 (22.7) | 8 (18.2) | 9 (29.0) | 0.281 |
| Dyslipidemia | 16 (21.3) | 9 (20.5) | 7 (22.6) | 1 |
| Coronary artery disease | 14 (18.7) | 8 (18.2) | 6 (19.4) | 1 |
| Malignancy | 11 (14.7) | 5 (11.4) | 6 (19.4) | 0.509 |
| Stroke | 10 (13.3) | 7 (15.9) | 3 (9.7) | 0.509 |
| Chronic lung disease | 7 (9.3) | 6 (13.6) | 1 (3.2) | 0.228 |
| Heart failure | 7 (9.3) | 4 (9.1) | 3 (9.7) | 1 |
| Liver disease | 5 (6.7) | 3 (6.8) | 2 (6.5) | 1 |
| Severe dengue at presentation | 61(81.3) | 32(72.7) | 29(93.5) | 0.034 |
| ICU parameters | ||||
| APACHE II score | 20 [16,28] | 17 [13,22] | 27 [21,42] | <0.001 |
| SOFA score | 11 [7,15] | 8 [5,12.8] | 16 [11,19] | <0.001 |
| Cardiac arrest before ICU admission | 7 (9.3) | 1 (2.3) | 6 (19.4) | 0.018 |
| Acute kidney injury at ICU admission | 41 (54.7) | 18 (40.9) | 23 (74.2) | 0.005 |
| Renal replacement therapy | 12 (16.9) | 4 (9.1) | 8 (25.8) | 0.063 |
| Respiratory failure at ICU admission | 47(62.7) | 22(50) | 25(80.6) | 0.008 |
| Mechanical ventilation | 57 (76.0) | 28 (63.6) | 29 (93.5) | 0.003 |
| Bloodstream infection | 18 (24.0) | 8 (18.2) | 10 (32.3) | 0.180 |
| Blood transfusion | 54 (72.9) | 30 (68.2) | 24 (77.4) | 0.441 |
| Platelets | 38 (50.7) | 20 (45.5) | 18 (58.1) | 0.351 |
| Whole blood | 28 (37.3) | 14 (31.8) | 14 (45.2) | 0.333 |
| Packed red blood cells | 37 (49.3) | 19 (43.2) | 18 (58.1) | 0.245 |
| Plasma | 30 (40.0) | 14 (31.8) | 16 (51.6) | 0.099 |
| Hospital course | ||||
| ICU stay (days) | 6 [3,14] | 9 [5.3,15.8] | 4 [1,8] | <0.001 |
| Hospital stay (days) | 13 [6,23] | 20 [11,35.5] | 4 [1,8] | <0.001 |
*Data are expressed as case number (%), mean ± standard deviation, or median [inter-quartile range].
APACHE II = acute physiology and chronic health evaluation II; SOFA = sequential organ failure assessment.