Figure 3. Meta-analyses of each effect.
Effect size (Cohen’s d) and 95% confidence interval are presented for Sirota et al., 2011, this replication attempt (RP:CB), and a meta-analysis to combine the two effects of day 11 tumor volume comparisons. Sample sizes used in Sirota et al., 2011 and this replication attempt are reported under the study name. Random effects meta-analysis of A549-derived tumors treated with vehicle (PBS) compared to 100 mg/kg cimetidine (meta-analysis p=0.0043), ACHN-derived tumors treated with vehicle (PBS) compared to 100 mg/kg cimetidine (meta-analysis p=0.917), and A549-derived tumors treated with vehicle (PBS) compared to 2 mg/kg doxorubicin (meta-analysis p=0.021). Additional details for these meta-analyses can be found at https://osf.io/jcghv/.