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. 2017 Jan 13;12:577–591. doi: 10.2147/IJN.S111284

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© 2017 Chai et al. This work is published and licensed by Dove Medical Press Limited

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Significant retention of plasma radioactivity (dpm/mL, y-axis) over time after dose for up to 24 h (x-axis) was observed in normal (A) rats administered 10 µCi 41 PG-Tr (△), but not in rats administered 17 kDa PG-Tr (▼) or Free-Tr (X). Plasma retention of PG was not observed in diabetic rats (B). Each data point is expressed as mean ± SEM (n=5). A comparison of the 41 kDa PG-Tr group with the other groups at each time interval revealed significant differences: ****P<0.0001; ***P<0.001; *P<0.05; two-way ANOVA with Bonferroni post hoc test.

Abbreviations: dpm, disintegration per minute; PG-Tr, radiolabeled poly-l-glutamic acid; Free-Tr, unbound radiolabels; SEM, standard error of mean; ANOVA, analysis of variance.