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. 2017 Jan 13;12:577–591. doi: 10.2147/IJN.S111284

Figure 2.

Figure 2

Significant accumulation of radioactivity (dpm/g tissue, y-axis) in the kidneys for up to 24 h (x-axis) was observed in normal rats (A) and diabetic rats (B) administered 10 µCi 41 kDa PG-Tr (△) and 17 kDa PG-Tr (▼), but not with Free-Tr (X). Renal accumulation of PG-Tr in diabetic rats was lower than in normal rats. Each data point is expressed as mean ± SEM (n=5). A comparison of the 41 kDa PG-Tr group with the Free-Tr group at each time interval revealed significant differences: ****P<0.0001. A comparison of the 41 kDa PG-Tr group with the free@ group at each time interval revealed significant differences: ^^^^P<0.0001; ^^^P<0.001; ^^P<0.01; ^P<0.05; ****P<0.0001; **P<0.01; two-way ANOVA with Bonferroni post hoc test.

Abbreviations: dpm, disintegration per minute per mL; PG-Tr, radiolabeled poly-l-glutamic acid; Free-Tr, free unbound radiolabels; SEM, standard error of mean; ANOVA, analysis of variance.