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. 2017 Jan 13;12:501–514. doi: 10.2147/IJN.S113607

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© 2017 Ringhieri et al. This work is published and licensed by Dove Medical Press Limited

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Scheme 1 — Scheme for the solid-phase synthesis of (C18)₂-K2N₃ (route A) and (C18)₂-K4N₃ (route B) monomers.

Note: The Rink amide resin is schematically represented with an empty circle.

Abbreviations: Fmoc, 9-fluorenylmethoxycarbonyl; Pip, piperidine; Mtt, 4-methyltrityl; HOBt, 1-hydroxybenzotriazole; PyBop, benzotriazole-1-yl-oxy trispyrrolidinophosphonium hexafluorophosphonate; DIPEA, N,N-diisopropylethylamine; TIS, triisopropylsilane; TFA, trifluoroacetic acid; DTT, dithiothreitol.