Skip to main content
. Author manuscript; available in PMC: 2017 Jan 19.
Published in final edited form as: J Bone Miner Res. 2014 Nov;29(11):2369–2381. doi: 10.1002/jbmr.2281

Figure 2.

Figure 2

Improvement of the scoliosis and other skeletal abnormalities in [Phospho1−/−; Spp1−/−] mice. (A, B) Radiographic images of Phospho1−/− and [Phospho1−/−; Spp1−/−] mice at 1 and 3 months of age. (A) [Phospho1−/−; Spp1−/−] mice showed slightly less scoliosis than Phospho1−/− mice at 1 month of age (arrows) but no change in the long bone abnormalities. (B) No scoliosis was observed at 3 months of age in [Phospho1−/−; Spp1−/−] mice (arrows). Less bowing of long bones and no fractures (in the tibias) are observed in [Phospho1−/−; Spp1−/−] mice than in Phospho1−/− mice. Images are representative of at least three individual mice for each genotype. Arrows show bowed long bones and fractures in the tibias in Phospho1−/− mice.