Figure 3.
C1QBP regulated RCC cell invasion and migration via YBX1. SW839 cells were transfected with pWPI-GFP, pWPI-C1QBP, pWPI-YBX1, or pWPI-C1QBP together with pWPI-YBX1. (A) 1 × 105 cells were plated onto the upper matrigel coated transwell chambers with 8 μm pore polycarbonate membrane for cell invasion assays. (B) 5 × 104 cells were plated onto the upper chamber with 8 μm pore polycarbonate membrane for cell migration assays. Overexpression of YBX1 could reverse C1QBP inhibited cell invasion and migration of RCC SW839 cells. (*P < 0.05, **P < 0.01).